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Efficacy and safety of a lidocaine/tetracaine medicated patch or peel for dermatologic procedures: a meta-analysis Full Text
Korean Journal of Anesthesiology, 06/08/2012
Evidence Based Medicine
Clinical Article
Kim WO et al. – The lidocaine/tetracaine medicated patch or peel is a well accepted, effective and safe method for minor dermatologic procedures based on pooled data of trials in terms of adequacy of cutaneous anesthesia and adverse effects.
Methods- Ten RCTs (574 patients) were included in this systemic review.
- Relevant studies were identified through searches of MEDLINE, SCOPUS and the Cochrane database library.
- The outcome was the adequacy of cutaneous anesthesia reflected in the patient's assessment of pain intensity during minor dermatologic procedures and adverse effects after application of the lidocaine/tetracaine medicated patch or peel versus placebo.
- The efficacy of the lidocaine/tetracaine patch or peel was consistently very significantly beneficial 30 or 60minutes after the application compared to placebo (Relative risk, RR: 2.5; Number needed to treat, NNT: 2.2).
- The authors did not identify any difference in the effectiveness of adequate analgesia between the lidocaine/tetracaine patch and peel (the number needed to treat or to harm, NNT 2.4 vs. 2.0).
- No serious side effects or adverse events were observed with the lidocaine/tetracaine medicated patch or peel and placebo.
- Minor skin reactions were transient and resolved without treatment (Odd ratio, OR: 1.4 and 95% confidence interval, CI: 0.9-2.1; NNT: 14.9).