Sequence analysis for detection of first-line drug resistance in Mycobacterium tuberculosis strains from a high-incidence setting Full Text
BMC Microbiology, 05/31/2012
Feuerriegel S et al. – The study reveals a good correlation between data from molecular and phenotypic resistance testing in this high–incidence setting. However, the fact that particular mutations in rpoB are not linked to high–level resistance is challenging and demonstrates that careful interpretation of molecular resistance assays is mandatory. In addition, certain variations, especially in gidB, appear to be phylogenetically informative polymorphisms rather than markers for drug resistance.