Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation
Archives of Dermatological Research, 06/20/2012
Nakajima H et al. – The findings indicate that Ax attenuates SCF–stimulated pigmentation by directly interrupting stem cell factor (SCF)–associated intracellular signaling linkages through increased expression of microphthalmia–associated transcription factor (MITF), which leads to the stimulated expression of melanogenic genes and proteins in a reactive oxygen species depletion–independent mechanism.



