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The safety and efficacy of red cell transfusions in neonates: a systematic review of randomized controlled trials
British Journal of Haematology,
Venkatesh V et al. – The methodological quality of many randomized controlled trials (RCTs) was poor. The design of future RCTs can be informed by the lessons from this review. Many trials failed to report on outcomes that would be considered of primary importance to clinicians. Consistent reporting of adverse events is required, and endpoints need to include neurodevelopmental outcomes.