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L-DOPA induced-endogenous 6-hydroxydopamine is the cause of aggravated dopaminergic neurodegeneration in Parkinsons disease patients
Medical Hypotheses, 06/15/2012
Borah A et al. – It is hypothesized that L–DOPA induced increase in endogenous 6–OHDA levels will have the ability to cause oxidative stress and mitochondrial dysfunctions that eventually leads to Lewy body formation in dopaminergic neurons resulting in its degeneration. Concomitant use of potent anti–oxidants along with L–DOPA would help in attenuating the neurodegeneration caused by endogenous 6–OHDA and would ultimately delay the progression of Parkinson’s disease.