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Atherosclerosis and arterial stiffness in obstructive sleep apnea-A cardiovascular magnetic resonance study
Atherosclerosis, 06/13/2012
Kylintireas I et al. – Obstructive sleep apnoea (OSA) is associated with increased carotid and aortic atheroma burden and with advanced, high risk carotid atherosclerotic plaques, but not with aortic stiffening.
Methods- 58 patients with OSA and 39 matched control subjects without OSA underwent CMR of the aorta and carotid arteries.
- Carotid and aortic wall thickness and aortic distensibility were measured.
- Multi–weighted, high resolution CMR imaging was used for carotid atheroma characterization according to the American Heart Association (AHA) atheroma classification, modified for CMR.
- Carotid [1.47±0.03mm vs. 1.26±0.05mm, (P<0.01)] and aortic wall thickness [2.95±0.09mm vs. 2.05±0.07mm, (P<0.001)] were increased in patients with OSA compared to controls.
- Aortic distensibility was decreased in patients with OSA [3.62±0.3 vs. 4.75±0.2mmHg–1×10–3, (P<0.05)].
- Prevalence of carotid plaque, average carotid atheroma class, and prevalence of high risk features of carotid atheroma were increased in patients with OSA (P<0.005 for all).
- On multivariate analysis, Oxygen desaturation index (ODI) emerged as an independent predictor of carotid and aortic wall thickness, but not of aortic stiffness.