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A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition
Critical Care Medicine, 05/25/2012
Clinical Article
Umpierrez GE et al. – The administration of parenteral nutrition containing soybean oil–based and olive oil–based lipid emulsion resulted in similar rates of infectious and noninfectious complications and no differences in glycemic control, inflammatory and oxidative stress markers, and immune function in critically ill adults.
Methods- A total of 100 patients were randomized to either soybean oil–based parenteral nutrition or olive oil–based parenteral nutrition for up to 28days.
- A total of 49 patients received soybean oil–based parenteral nutrition (age 51±15yrs, body mass index 27±6kg/m2, and Acute Physiology and Chronic Health Evaluation II score 15.5±7 [±SD]), and a total of 51 patients received olive oil–based lipid emulsion in parenteral nutrition (age 46±19yrs, body mass index 27±8kg/m2, and Acute Physiology and Chronic Health Evaluation II score 15.1&±6 [±SD]) for a mean duration of 12.9±8days.
- The mean hospital blood glucose concentration during parenteral nutrition was 129±14mg/dL, without differences between groups.
- Patients treated with soybean oil–based and olive oil–based parenteral nutrition had a similar length of stay (47±47days and 41±36days, p=.49), mortality (16.3% and 9.8%, p=.38), nosocomial infections (43% vs. 57%, p=.16), and acute renal failure (26% vs. 18%, p=.34).
- In addition, there were no differences in inflammatory and oxidative stress markers or in granulocyte and monocyte functions between groups.