The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes
Annals of Rheumatic Diseases, 05/25/2012
Rhodes B et al. – The R77H variant impairs a broad range of CR3 effector functions in human monocytes. This study discusses how perturbation of this pathway may predispose to systemic lupus erythematosus (SLE).