Increased oxidative stress in human fetal membranes overlying the cervix from term non-labouring and post labour deliveries
Chai M et al. – There was no difference in expression or activity in catalase, GPx and glutathione reductase (GSR) between no labour and post labour fetal membranes. In primary amnion cells, SOD supplementation significantly augmented IL–1β induced MMP–9 expression and activity. In summary, non–labouring SC fetal membranes are characterised by reduced antioxidant enzyme activity when compared to distal membranes, and, as such, may be more susceptible to oxidative damage and thus membrane rupture.