Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection
Cell Host & Microbe, 05/25/2012
Sloves PJ et al. – Conditional ablation of TgSORTLR disrupts rhoptry and microneme biogenesis, inhibits parasite motility, and blocks both invasion into and egress from host cells. Thus, the sortilin–like receptor is essential for protein trafficking and the biogenesis of key secretory organelles in Toxoplasma.