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High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates
Alimentary Pharmacology and Therapeutics, 05/18/2012
Clinical Article
Sanchez–Delgado J et al. – Cure rates of the combination of esomeprazole, amoxicillin and metronidazole are high and the treatment was well tolerated. This pilot study warrants the comparison of this schedule with current standards.
Methods- Patients from eight hospitals were included.
- Helicobacter pylori status was assessed by at least one of the following: histology, culture, rapid urease test or urea breath test (UBT).
- Ten–day treatment was prescribed comprising esomeprazole 40 mg twice a day plus amoxicillin 1 g and metronidazol 500 mg both three times a day.
- Helicobacter pylori cure was assessed by UBT.
- A hundred and thirty–six patients were enrolled.
- Mean age was 52.6 ± 16 years and 59.6% of patients were men.
- Main indications for treatment were: uninvestigated dyspepsia (13.6%); functional dyspepsia (18.2%); gastric ulcer (21.8%); and duodenal ulcer (39.8%).
- Helicobacter pylori eradication was achieved in 112 of the 127 patients who returned for follow–up.
- Eradication rates were 82.4% (95% CI: 74.7–88.1) by intention–to–treat analysis and 88.2% (95% CI: 81.2–92.8) by per protocol.
- Treatment was well tolerated and no major side effects were reported.
- Nine patients complained of mild side effects.