High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates
Alimentary Pharmacology and Therapeutics, 05/18/2012
Sanchez–Delgado J et al. – Cure rates of the combination of esomeprazole, amoxicillin and metronidazole are high and the treatment was well tolerated. This pilot study warrants the comparison of this schedule with current standards.Methods
- Patients from eight hospitals were included.
- Helicobacter pylori status was assessed by at least one of the following: histology, culture, rapid urease test or urea breath test (UBT).
- Ten–day treatment was prescribed comprising esomeprazole 40 mg twice a day plus amoxicillin 1 g and metronidazol 500 mg both three times a day.
- Helicobacter pylori cure was assessed by UBT.
- A hundred and thirty–six patients were enrolled.
- Mean age was 52.6 ± 16 years and 59.6% of patients were men.
- Main indications for treatment were: uninvestigated dyspepsia (13.6%); functional dyspepsia (18.2%); gastric ulcer (21.8%); and duodenal ulcer (39.8%).
- Helicobacter pylori eradication was achieved in 112 of the 127 patients who returned for follow–up.
- Eradication rates were 82.4% (95% CI: 74.7–88.1) by intention–to–treat analysis and 88.2% (95% CI: 81.2–92.8) by per protocol.
- Treatment was well tolerated and no major side effects were reported.
- Nine patients complained of mild side effects.