Added predictive ability of the cha2ds2vasc risk score for stroke and death in patients with atrial fibrillation: the prospective danish diet, cancer, and health cohort study
Circulation: Cardiovascular Quality and Outcomes,

Larsen TB et al. – Both the CHADS2 as well as the CHA2DS2VASc risk score can exclude a large proportion of patients from having high risk of stroke or death. However, using the CHA2DS2VASc risk score, fewer patients will fulfill the criterion for low risk (and are truly low risk for thromboembolism). For every 10 extra patients transferred to the treatment group at 5 years, using the CHA2DS2VASc risk score, 1 patient would have had a stroke that might have been avoided with effective treatment.

Methods
  • Authors included 1603 nonanticoagulated patients with incident atrial fibrillation from a Danish prospective cohort study of 57 053 middle-aged men and women.
  • The Net Reclassification Improvement was calculated as a measure to estimate any overall improvement in reclassification with the CHA2DS2VASc sore as an alternative to the CHADS2 score.
  • After 1-year follow-up, crude incidence rates were 3.4 per 100 person-years for stroke and 13.6 for death.
  • After a mean follow-up of 5.4 years (±3.7 years), the crude incidence rates for stroke and death were 1.9 and 5.6, respectively.

Results
  • During the entire observation period, the c-statistics and negative predictive values were similar for both risk scores.
  • The Net Reclassification Improvement analysis showed that 1 of 10 reclassified atrial fibrillation patients would have been upgraded correctly using the CHA2DS2VASc score.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Physician Assistant

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Physician Assistant Articles

1 Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): A randomised, multicentre, open-label, phase 3 non-inferiority trial The Lancet Oncology, October 22, 2014    Clinical Article

2 Rice consumption and risk of cardiovascular disease: Results from a pooled analysis of 3 U.S. cohorts American Journal of Clinical Nutrition, December 2, 2014    Clinical Article

3 Nonobstructive coronary artery disease and risk of myocardial infarction JAMA, November 6, 2014    Evidence Based Medicine    Clinical Article

4 Effects of regular consumption of different forms of almonds and hazelnuts on acceptance and blood lipids European Journal of Nutrition, December 12, 2014    Clinical Article

5 Nutritional and physical activity interventions to improve immunity American Journal of Lifestyle Medicine, December 12, 2014    Review Article

6 Calcium channel blocker compared with angiotensin receptor blocker for patients with hypertension: a meta-analysis of randomized controlled trials The Journal of Clinical Hypertension, August 13, 2014    Evidence Based Medicine    Review Article    Clinical Article

7 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

8 Comparative study of glucose homeostasis, lipids and lipoproteins, HDL functionality, and cardiometabolic parameters in modestly severely obese African Americans and White Americans with prediabetes: implications for the metabolic paradoxes Diabetes Care, December 24, 2014    Clinical Article

9 Dietary fat increases vitamin D-3 absorption Journal of the Academy of Nutrition and Dietetics, December 5, 2014    Clinical Article

10 Breath analysis in inflammatory bowel diseases Alimentary Pharmacology and Therapeutics, December 24, 2014    Review Article

11 The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective randomized controlled trial Hepatology, December 24, 2014    Clinical Article

12 Male pattern baldness in relation to prostate cancer risks: An analysis in the Vitamins and lifestyle (VITAL) cohort study The Prostate, December 12, 2014    Clinical Article

13 Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence The Journal of Allergy and Clinical Immunology, December 24, 2014    Clinical Article

14 Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis Full Text BMC Medicine, December 3, 2014    Free full text

15 Ocular toxoplasmosis in the United States: Recent and remote infections Clinical Infectious Diseases, December 24, 2014    Clinical Article

16 Accuracy of fibroscan, compared with histology, in analysis of liver fibrosis in patients with hepatitis B or C: A US Multi-center Study Clinical Gastroenterology and Hepatology , December 24, 2014    Clinical Article

17 Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis The American Journal of Gastroenterology, December 24, 2014    Clinical Article

18 Compassionate Use of Bedaquiline for the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Interim Analysis of a French Cohort Clinical Infectious Diseases, December 24, 2014    Clinical Article

19 Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis Alimentary Pharmacology and Therapeutics, December 24, 2014    Clinical Article

20 Validation of the hepatoma arterial embolization prognostic score in European and Asian populations and proposed modification Clinical Gastroenterology and Hepatology , December 24, 2014    Clinical Article

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physicianmore

Looking for a physician job? Let us help!

Register now for our free job placement service.
A career consultant will contact you soon.
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List