Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer Full Text
Clinical Cancer Research, 05/16/2012
Saylor PJ et al. – Unbiased metabolomic analyses revealed expected, novel, and unexpected results. Steroid levels fell, consistent with the effects of androgen deprivation therapy (ADT). Most bile acids and their metabolites increased during ADT, a novel finding. Biomarkers of lipid metabolism and insulin resistance fell, unexpected given that ADT has been shown to increase fasting insulin.