Effect of Intensive Versus Standard Blood Pressure Control on Depression and Health-Related Quality of Life in Type 2 Diabetes: The ACCORD trial Full Text
Diabetes Care, 05/18/2012
O’Connor PJ et al. – Intensive blood pressure (BP) control in the ACCORD trial did not have a clinically significant impact, either positive or negative, on depression or patient–reported health–related quality of life (HRQL).Methods
- Subjects were 1,028 ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial HRQL substudy participants who completed baseline and one or more 12–, 36–, or 48–month HRQL evaluations.
- Multivariable linear regression assessed impact of BP treatment assignment on change in HRQL.
- Over 4.0 years of follow–up, no significant differences occurred in five of six HRQL measures.
- Those assigned to intensive (vs. standard) BP control had statistically significant worsening of the Medical Outcomes Study 36–item short–form health survey (SF36) physical component scores (–0.8 vs. –0.2; P = 0.02), but magnitude of change was not clinically significant.
- Findings persisted across all prespecified subgroups.