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Genetic variants of the MBL2 gene are associated with mortality in pneumococcal sepsis
Diagnostic Microbiology and Infectious Disease, 06/01/2012
Garnacho–Montero J et al. – Factors associated independently with in–hospital mortality were SNP MBL2 AO/OO (adjusted hazard ratios [aHR] 3.2, 95% confidence interval [CI] 1.01–9.8) and septic shock (aHR 15.3, 95% CI 3.5–36.5), whereas first adequate antibiotic dose ≤4 h was a protective factor (aHR 0.2, 95% CI 0.06–0.8). SNP MBL2 AO/OO (aHR 2.2, 95% CI 1.1–8.1) remained as a variable independently associated with 90–day mortality. In conclusion, variant alleles in the MBL2 gene are independently associated with in–hospital and medium–term mortalities in patients admitted to the hospital with pneumococcal sepsis.