Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography
The American Journal of Cardiology, 05/31/2012
Horne BD et al. – Prospective hypothesis testing showed that routine periodic fasting was associated with a lower prevalence of DM in patients undergoing coronary angiography. A reported fasting association with a lower CAD risk was also validated and fasting associations with lower glucose and BMI were found.Methods
- This study prospectively tested whether routine periodic fasting is associated with diabetes mellitus (DM).
- Patients (n = 200) undergoing coronary angiography were surveyed for routine fasting behavior before their procedure.
- DM diagnosis was based on physician reports of current and historical clinical and medication data.
- Secondary end points included CAD (physician reported for ?1 lesion of ?70% stenosis), glucose, and body mass index (BMI).
- Meta-analyses were performed by evaluation of these patients and 448 patients from a previous study.
- DM was present in 10.3% of patients who fasted routinely and 22.0% of those who do not fast (odds ratio [OR] 0.41, 95% confidence interval [CI] 0.17 to 0.99, p = 0.042).
- CAD was found in 63.2% of fasting and 75.0% of nonfasting patients (OR 0.42, CI 0.21 to 0.84, p = 0.014), and in nondiabetics this CAD association was similar (OR 0.38, CI 0.16 to 0.89, p = 0.025 (108 ± 36 vs 115 ± 46 mg/dl, p = 0.047) and BMI (27.9 ± 5.3 vs 29.0 ± 5.8 kg/m2, p = 0.044).
- Meta-analysis showed modest differences for fasters versus nonfasters in glucose concentrations).