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Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function
Journal of Nephrology,
Clinical Article
Meng L et al. – Besides the traditional risk factors, a higher level of serum cystatin C might be another independent risk factor for cardiovascular events, even in those with relatively normal renal function.
Methods- Residents (n=724) with relatively normal renal function (estimated glomerular filtration rate [eGFR] =60 ml/min per 1.73 m2), who attended a community hospital in an urban district of Beijing, were recruited in the study.
- Risk factors for cardiovascular events were analyzed.
- Compared with subjects without cardiovascular events, those with cardiovascular events were older (p<0.000001) and had a higher proportion of males (p<0.01), those with diabetes (p<0.05) and smokers (p<0.05).
- Subjects with cardiovascular events had lower levels of serum high-density lipoprotein cholesterol (HDL-C) and eGFR than those without (p<0.05, p<0.01, respectively).
- The serum level of cystatin C was significantly higher in subjects with cardiovascular events than in subjects without cardiovascular events (p<0.01).
- Multivariable logistic regression analysis showed that the independent predictors of cardiovascular events were age, hypertension and serum level of cystatin C (higher than 0.88mg/L).