Targeting macrophages in the tumor environment to enhance the efficacy of OX40 therapy
Immunology, 05/14/2012
Gough MJ et al. – The data demonstrate that macrophages in the tumor environment limit the effectiveness of OX40–based immunotherapy, and combination therapies that target both the cell–mediated immune response and the suppressive tumor environment will be required for translation of effective immunotherapies to patients with established tumors.



