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Intravenous ketamine compared with diclofenac suppository in suppressing acute postoperative pain in women undergoing gynecologic laparoscopy
Journal of Anesthesia, 05/14/2012
Clinical Article
Vosoughin M et al. – Diclofenac 100–mg suppositories were more effective in suppressing acute pain than 0.15mg/kg intravenous ketamine in women undergoing elective gynecologic laparoscopy, with fewer untoward complications.
Methods- In a double–blind, randomized clinical trial, 80 patients were selected and entered the study.
- After the induction of general anesthesia, one group received 0.15mg/kg intravenous ketamine and the other group received a 100–mg rectal diclofenac suppository.
- The two groups were compared regarding acute pain scores, postoperative morphine requirements, and untoward complications.
- Pain scores and morphine requirements were lower in the rectal diclofenac suppository group at the 1st, 3rd, and 6th postoperative hours.
- Higher incidences of postoperative nausea and vomiting (PONV), delusions, and oral secretions were observed in the ketamine group.