mdlinx mdlinx
Latest (538) Full Text Articles (11656) Article Summary

Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan
Hypertension Research,  Clinical Article

Ito S et al. – Hyperuricemia may be a major determinant of increased cardiovascular risk in chronic kidney disease (CKD) stage 3A, and serum uric acid level (SUA) may be involved in the progression of CKD. Changes in the glomerular filtration rate (GFR) influence the rate of cardiovascular event (CVE).

Methods
  • This subanalysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J–HEALTH) study included 7629 patients, in whom the serum creatinine level was measured at least twice.
  • The study examined the impact of hyperuricemia (SUA ≥7mgdl–1) on CVE according to the level of renal dysfunction and whether early changes in SUA predicted future glomerular filtration rates (GFRs).
  • The mean follow–up period was 3.1 years.
  • The patients were divided into three groups according to the baseline estimated GFR (eGFR): groups A, B and C with eGFR <45, 45–59 and ≥60mlmin–1 per 1.73m2, respectively. eGFR increased from 38.1 to 57.6, from 52.8 to 67.5 and from 74.7 to 80.7mlmin–1 per 1.73m2 in groups A, B and C, respectively.

Results
  • In non–hyperuricemic patients, the CVE rate was 10.83, 4.98 and 4.21/1000 person–years in groups A, B and C, respectively, while in hyperuricemic patients, the corresponding values were 14.18, 17.02 and 5.93.
  • Thus, hyperuricemia increased the risk of CVE only in group B (relative risk (RR) 3.43 (95% confidence interval (CI) 1.55 to 7.60); P<0.002).
  • The final change in the eGFR was negatively correlated with the change in SUA from baseline to year 1 (P<0.001).
  • CVEs were more frequent in those with a decrease in eGFR.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Physician Assistant

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Physician Assistant Articles

Last month's top read Top Articles of 2013

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physicianmore

Other Topics in Physician Assistant

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close