Phase II study of sorafenib in patients with relapsed or refractory lymphoma
British Journal of Haematology, 05/11/2012Guidetti A et al.
Compared with patients with progressive disease (PD), responsive patients had significantly higher baseline levels of extracellular signal–regulated kinase phosphorylation and autophagy and presented a significant reduction of these parameters after 1 month of therapy. Sorafenib was well tolerated and had a clinical activity that warrants development of combination regimens.
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