Activated innate immunity and the involvement of CX3CR1–fractalkine in promoting hematuria in patients with IgA nephropathy
Kidney International, 05/10/2012
Cox SN et al. – The authors found a defect in antigen handling in peripheral blood mononuclear cells of immunoglobulin A nephropathy patients with a specific increase of CX3CR1. This constitutive upregulation of glomerular and urinary fractalkine suggests an involvement of the CX3CR1–fractalkine axis in the exacerbation of gross hematuria.