Impact of shed blood products on stimulated cytokine release in an in vitro model of transfusion
Acta Anaesthesiologica Scandinavica, 05/15/2012
Schneider SO et al. – Shed blood and its components caused a dose–independent immunomodulation as indicated by a suppressed stimulated TNF–α release. Leukocytes seem to play a minor role, as observed a sustained suppression after transfusion of γ–irradiated shed blood. Only the elimination of soluble factors by centrifugation and followed by an additional washing step prevented the observed suppression of TNF–α. Thus, the authors assume that washing of shed blood can prevent potential detrimental effects.