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Vitamin D Deficiency in Postmenopausal Breast Cancer Survivors
Journal of Women's Health, 05/09/2012
Clinical Article
Friedman CF et al. – Hypovitaminosis D is common in BCS, and those who are nonwhite or overweight are at a higher risk of deficiency despite taking vitamin D supplements.
Methods- Authors collected data on 391 postmenopausal women with stage I–III breast cancer on AI therapy.
- Vitamin D levels were measured by radioimmunoassay from patients' sera; deficiency was defined as a level < 30 ng/mL.
- Multivariate models were created to assess risk factors for deficiency.
- The median vitamin D level was 35 ng/mL (range 6.78–93.15), and 35% of women were vitamin D deficient.
- When adjusting for age and vitamin D supplementation, minority participants were more likely to be vitamin D deficient than white women, (adjusted odds ratio [AOR] 2.18, 95% confidence interval [CI]1.22–3.89, p=0.009).
- Both overweight (AOR 3.05, 95% CI 1.72–5.41, p<0.001) and obese participants (AOR 3.21, 95% CI 1.79–5.78, p<0.001) had higher deficiency rates than did normal weight participants.