Developmental Trajectory and Environmental Moderation of the Effect of ALDH2 Polymorphism on Alcohol Use
Alcoholism: Clinical and Experimental Research, 05/08/2012
Irons DE et al. – The protective effect of the aldehyde dehydrogenase 2 (ALDH2)*2 allele increases over the course of adolescence and young adulthood and is modified by the environmental influence of parental alcohol use and misuse. As such, ALDH2 provides a model system for exploring the nature of gene–environment interplay across development.