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Diagnosis of Periprosthetic Joint Infection Using Synovial C-Reactive Protein
Journal of Arthroplasty, 05/21/2012
Clinical Article
Parvizi J et al. – The authors believe that synovial C–reactive protein (CRP) assay holds great promise as a diagnostic marker for periprosthetic joint infection (PJI).
Methods- Synovial fluid samples were collected prospectively from 63 patients undergoing revision or primary joint arthroplasty.
- All patients were divided into septic vs aseptic groups.
- There were 43 patients in the aseptic group and 20 patients in the septic group.
- There was a statistically significant difference in the mean synovial CRP between the septic cohort at 40 mg/L vs a mean of 2 mg/L for aseptic failure (P < .0001).
- The sensitivity was 85% with 95% specificity at a threshold of 9.5 mg/L.
- The area under the curve was 0.92.