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Plasma total antioxidant status and cognitive impairments in schizophrenia
Schizophrenia Research, 05/09/2012
Clinical Article
Zhang XY et al. – The authors' findings suggest that oxidative stress may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment.
Methods- The authors recruited 296 chronic schizophrenia patients and 181 healthy control subjects and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and plasma total antioxidant status (TAS) in both groups.
- Schizophrenia symptoms were assessed using the positive and negative syndrome scale (PANSS).
- The authors' results showed that TAS levels were significantly lower in patients than controls (179.6±81.0U/ml vs. 194.8±46.0U/ml, p<0.05).
- Cognitive scores on the RBANS and nearly all of its five subscales (all p<0.001) except for the Visuospatial/Constructional index (p>0.05) were significantly lower in schizophrenia patients than normal controls.
- For the patients, TAS was inversely associated with some domains of cognitive deficits in schizophrenia, such as Attention and Immediate Memory.