mdlinx mdlinx
Latest (546) Full Text Articles (11656) Article Summary

Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: Implications for prior therapy in clinical trials
Urologic Oncology: Seminars and Original Investigations,  Clinical Article

Pond GR et al. – In this hypothesis–generating analysis, patients treated with docetaxel–based chemotherapy following prior ketoconazole (KC) had numerically and consistently worse outcomes than patients not exposed to prior KC. Although the estimated differences did not attain statistical significance, evaluation of outcomes with docetaxel in particular, and all classes of novel and emerging agents following Abiraterone acetate, is of clinical importance, given its more potent androgen synthesis inhibition compared with KC. Drug development should take into account the potential impact of previous therapy.

Methods
  • A randomized phase II trial of men with mCRPC treated with DP + AT–101 (bcl–2 inhibitor) vs. DP plus placebo was analyzed.
  • Both arms were combined for analysis as no significant differences were seen.
  • Overall survival (OS), progression–free survival (PFS), objective response (ORR), pain, and prostate–specific antigen (PSA) response rates were estimated with and without prior KC.
  • Cox proportional hazards regression models were used to estimate the effect of covariates on OS.

Results
  • Of 220 evaluable men, 40 (18.2%) received prior KC. The median OS with DP–based therapy of KC–naive patients (18.3 months, 95% CI: 15.0, 24.5) and post–KC patients (17.0 months, 95% CI: 9.9, 20.4) was not statistically different (P = 0.20).
  • After controlling for prognostic classifications, analyses demonstrated consistent trends for worsening of OS after KC, with (hazard ratios (HRs) 1.33–1.46.
  • Similar unfavorable trends were observed for ORR, PSA declines, and PFS.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Physician Assistant

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Physician Assistant Articles

Last month's top read Top Articles of 2013

1 Empirical validation of the information–motivation–behavioral skills model of diabetes medication adherence: a framework for intervention Diabetes Care, March 26, 2014    Clinical Article

2 Evidence-informed frameworks for cost-effective cancer care and prevention in low, middle, and high-income countries The Lancet Oncology, March 10, 2014    Clinical Article

3 Beta blockers in hypertension: studies and meta-analyses over the years Canadian Journal of Cardiology, March 21, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Vitamin D and cardiovascular disease Circulation Research, February 3, 2014    Review Article    Clinical Article

5 Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: Investigation in the QUASAR2 study, systematic review, and meta-analysis Journal of Clinical Oncology, March 19, 2014    Evidence Based Medicine

6 Tea consumption and prostate cancer: An updated meta-analysis Full Text World Journal of Surgical Oncology, February 24, 2014    Free full text    Evidence Based Medicine    Review Article

7 Statin treatment, new-onset diabetes, and other adverse effects: a systematic review Current Cardiology Reports, February 12, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 The antithrombotic effects of statins Annual Review of Medicine, March 20, 2014    Review Article    Clinical Article

9 Effect of citalopram on agitation in Alzheimer disease: The CitAD randomized clinical trial JAMA, February 19, 2014    Evidence Based Medicine    Clinical Article

10 Current evidence on physical therapy in patients with adhesive capsulitis: What are we missing? Clinical Rheumatology, January 10, 2014    Review Article

11 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

12 U.S. physicians perspective of adult vaccine delivery Annals of Internal Medicine, February 4, 2014    Evidence Based Medicine    Clinical Article

13 Comparison of pregabalin with pramipexole for restless legs syndrome New England Journal of Medicine, February 14, 2014    Evidence Based Medicine    Clinical Article

14 Portion sizes for children are predicted by parental characteristics and the amounts parents serve themselves American Journal of Clinical Nutrition, February 13, 2014    Clinical Article

15 Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial Complementary Therapies in Medicine, March 4, 2014    Clinical Article

16 Prevalence of childhood and adult obesity in the United States, 2011-2012 JAMA, February 26, 2014    Evidence Based Medicine    Clinical Article

17 An inactivated enterovirus 71 vaccine in healthy children New England Journal of Medicine, February 28, 2014    Evidence Based Medicine    Clinical Article

18 Coffee consumption and prostate cancer risk: An updated meta-analysis Cancer Causes and Control, March 3, 2014    Evidence Based Medicine    Clinical Article

19 Clevidipine in acute heart failure: results of the a study of blood pressure control in acute heart failure—a pilot study (PRONTO) American Heart Journal, March 27, 2014    Clinical Article

20 Diet-induced weight loss: the effect of dietary protein on bone Journal of the Academy of Nutrition and Dietetics, January 6, 2014    Clinical Article

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physicianmore

Other Topics in Physician Assistant

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close