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Association of ocular pseudoexfoliation syndrome with ischaemic heart disease, arterial hypertension and diabetes mellitus
Acta Ophthalmologica, 05/16/2012
Clinical Article
Speckauskas M et al. – Pseudoexfoliation syndrome (PEX) prevalence is high in Lithuania. No clear PEX association with ischaemic heart disease, arterial hypertension and diabetes mellitus was proven after controlling for effect of age.
Methods- In this population-based study, 1065 participants aged 45-72 years were randomly drawn from the population register of Kaunas, Lithuania.
- They were classified as having PEX if any pseudoexfoliation material was determined by a slit-lamp examination in at least one eye.
- The data were acquired from questionnaire; register of myocardial infarction, electrocardiogram, biochemical blood analyses and blood pressure measurement were used to determine IHD, AH, DM and smoking habits.
- Poststratification weights based on Kaunas population sex and age distribution were applied.
- Pseudoexfoliation syndrome was estimated in 9% of a population.
- The AH rate was higher in PEX subjects than in non-PEX subjects (p = 0.017) and the rates of IHD, DM and cholesterol levels did not differ statistically significantly.
- Chi-square linear-by-linear association test found higher AH rate in unilateral PEX subjects and even higher AH rate in bilateral PEX subjects than in non-PEX subjects (p = 0.014).
- Pseudoexfoliation syndrome increased odds for AH by 1.8 times (p = 0.021).
- Median of systolic blood pressure was higher in the PEX group than in non-PEX group (p = 0.04).
- But all associations could not be confirmed after adjusting for age.
- Smoking duration increased age-adjusted odds for PEX.
- Pseudoexfoliation syndrome did not increase risk for IHD, AH or DM.