Angiopoietin-2 in acute liver failure
Critical Care Medicine,

Hadem J et al. – The data show that circulating Angiopoietin–2, which potentially originates from the injured liver, correlates with several features of multiple organ dysfunction syndrome and independently predicts outcome. Tie2 agonists may have potential as an endothelium–targeted therapy to ameliorate multiple organ dysfunction syndrome and improve outcome in acute liver failure.

Methods
  • Thirty-seven patients with acute liver failure and 20 healthy control subjects.
  • Angiopoietin-2 levels were measured in sera from 37 patients with acute liver failure on admission and from 20 healthy control subjects.
  • Median age of patients with acute liver failure was 34yrs, 29 were female, and 21 developed encephalopathy grade 3 or greater.

Results
  • Nine patients survived to day 28 without transplantation, five died without transplantation, and 23 received a transplant.
  • Median (interquartile range) Angiopoietin-2 serum concentrations steadily increased across the following groups: healthy control subjects (1.4 [0.9–1.7]ng/mL), patients with transplant-free recovery (10.0 [4.7–12.1]ng/mL), and patients who reached the composite end point of death or emergency liver transplantation (16.8 [11.3–39.5]ng/mL).
  • Angiopoietin-2 release correlated strongly with surrogate markers of organ dysfunction and disease severity measures (lactate, platelet count, Sequential Organ Failure Assessment score, and Simplified Acute Physiology Score III).
  • Angiopoietin-2 levels were higher in patients with acute kidney injury and patients on mechanical ventilation.
  • Furthermore, Angiopoietin-2 levels were closely associated with Bilirubin–Lactate–Etiology score but not with other liver-specific markers.
  • Unadjusted and adjusted Cox’s proportional hazards analyses identified Angiopoietin-2 as a predictor of the composite end point of death or transplantation.
  • Finally, immunohistological studies showed that Angiopoietin-2 protein was upregulated in acute liver failure explants compared with matched liver biopsies obtained at baseline.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Physician Assistant

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Physician Assistant Articles

1 Dance for Parkinson's: A new framework for research on its physical, mental, emotional, and social benefits Complementary Therapies in Medicine, June 17, 2014    Review Article

2 Statins in the elderly: an answered question Current Opinion in Cardiology, June 9, 2014    Evidence Based Medicine    Review Article    Clinical Article

3 Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial American Journal of Clinical Nutrition, July 10, 2014    Clinical Article

4 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 25, 2014    Evidence Based Medicine    Clinical Article

5 Calcium channel blocker compared with angiotensin receptor blocker for patients with hypertension: a meta-analysis of randomized controlled trials The Journal of Clinical Hypertension, August 13, 2014    Evidence Based Medicine    Review Article    Clinical Article

6 Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States BMJ, June 24, 2014    Evidence Based Medicine    Clinical Article

7 The effectiveness of metoprolol versus atenolol on prevention of all-cause and cardiovascular mortality in a large Chinese population: A cohort study International Journal of Cardiology, June 27, 2014    Clinical Article

8 A statin a day to keep the doctor away? comparing aspirin and statins for primary prevention of cardiovascular disease Annals of Pharmacotherapy, August 7, 2014    Clinical Article

9 New treatments for type 2 diabetes: Cardiovascular protection beyond glucose lowering Heart, Lung, and Circulation, September 4, 2014    Clinical Article

10 Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study American Journal of Clinical Nutrition, July 2, 2014    Clinical Article

11 Efficacy of high-dose versus standard-dose influenza vaccine in older adults New England Journal of Medicine, August 15, 2014    Evidence Based Medicine    Clinical Article

12 Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid Journal of Thrombosis and Haemostasis, September 25, 2014    Clinical Article

13 Efficacy and tolerability of triple-combination therapy with olmesartan, amlodipine, and hydrochlorothiazide: a subgroup analysis of patients stratified by hypertension severity, age, sex, and obesity The Journal of Clinical Hypertension, September 26, 2014    Clinical Article

14 Impact of adjuvant radiotherapy on survival of patients with node-positive prostate cancer Journal of Clinical Oncology, September 26, 2014    Clinical Article

15 Short-term and long-term causes of death in patients with alcoholic hepatitis in Denmark Clinical Gastroenterology and Hepatology , September 26, 2014    Clinical Article

16 Cost effectiveness of response-guided therapy with peginterferon in the treatment of chronic hepatitis B Clinical Gastroenterology and Hepatology , September 26, 2014    Clinical Article

17 Rate of detection of advanced neoplasms in proximal colon by simulated sigmoidoscopy vs fecal immunochemical tests Clinical Gastroenterology and Hepatology , September 26, 2014    Clinical Article

18 Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users: data from a prospective multicenter capsule endoscopy registry Gastrointestinal Endoscopy, September 26, 2014    Clinical Article

19 Relationship between changes in serum levels of keratin 18 and changes in liver histology in children and adults with nonalcoholic fatty liver disease Clinical Gastroenterology and Hepatology , September 26, 2014    Review Article

20 New insulin glargine 300 units·mL-1 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 units·mL-1 Diabetes Care, September 26, 2014    Clinical Article

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physicianmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close