Radical prostatectomy vs radiation therapy and androgen-suppression therapy in high-risk prostate cancer
BJU International,  Clinical Article

Westover K et al. – Initial treatment with radical prostatectomy as compared with combined–modality therapy was not associated with an increased risk of prostate cancer–specific mortality in men with Gleason score 8–10 prostate cancer.

Methods
  • Men with localised high-risk prostate cancer based on a Gleason score of 8–10 were selected for study from Duke University (285 men), treated between January 1988 and October 2008 with RP or from the Chicago Prostate Cancer Center or within the 21st Century Oncology establishment (372) treated between August 1991 and November 2005 with CMT.
  • Fine and Gray multivariable regression was used to assess whether the risk of prostate cancer-specific mortality differed after RP as compared with CMT adjusting for age, cardiac comorbidity and year of treatment, and known prostate cancer prognostic factors.

Results
  • As of January 2009, with a median (interquartile range) follow-up of 4.62 (2.4-8.2) years, there were 21 prostate cancer-specific deaths.
  • Treatment with RP was not associated with an increased risk of prostate cancer-specific mortality compared with CMT (adjusted hazard ratio [HR] 1.8, 95% confidence interval [CI] 0.6-5.6, P= 0.3).
  • Factors associated with an increased risk of prostate cancer-specific mortality were a PSA concentration of <4 ng/mL (adjusted HR 6.1, 95% CI 2.3–16, P < 0.001) as compared with ≥4 ng/mL, and clinical category T2b, c (adjusted HR 2.9; 95% CI 1.1–7.2; P= 0.03) as compared with T1c, 2a.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Physician Assistant

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Physician Assistant Articles

1 Dengue outlook for the World Cup in Brazil: An early warning model framework driven by real-time seasonal climate forecasts The Lancet Infectious Diseases, May 27, 2014    Clinical Article

2 Dance for Parkinson's: A new framework for research on its physical, mental, emotional, and social benefits Complementary Therapies in Medicine, June 17, 2014    Review Article

3 Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial American Journal of Clinical Nutrition, July 10, 2014    Clinical Article

4 Statins in the elderly: an answered question Current Opinion in Cardiology, June 9, 2014    Evidence Based Medicine    Review Article    Clinical Article

5 Calcium channel blocker compared with angiotensin receptor blocker for patients with hypertension: a meta-analysis of randomized controlled trials The Journal of Clinical Hypertension, August 13, 2014    Evidence Based Medicine    Review Article    Clinical Article

6 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 25, 2014    Evidence Based Medicine    Clinical Article

7 Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States BMJ, June 24, 2014    Evidence Based Medicine    Clinical Article

8 The role of vitamin supplementation in the prevention of cardiovascular disease events Full Text Clinical Cardiology, May 30, 2014    Free full text    Review Article

9 The effectiveness of metoprolol versus atenolol on prevention of all-cause and cardiovascular mortality in a large Chinese population: A cohort study International Journal of Cardiology, June 27, 2014    Clinical Article

10 Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis New England Journal of Medicine, May 21, 2014    Evidence Based Medicine    Clinical Article

11 Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study American Journal of Clinical Nutrition, July 2, 2014    Clinical Article

12 A statin a day to keep the doctor away? comparing aspirin and statins for primary prevention of cardiovascular disease Annals of Pharmacotherapy, August 7, 2014    Clinical Article

13 Efficacy of high-dose versus standard-dose influenza vaccine in older adults New England Journal of Medicine, August 15, 2014    Evidence Based Medicine    Clinical Article

14 Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: a pooled analysis of 4500 patients Heart, Lung, and Circulation, August 15, 2014    Clinical Article

15 Combination therapy with aliskiren versus ramipril or losartan added to conventional therapy in patients with type 2 diabetes mellitus, uncontrolled hypertension and microalbuminuria Journal of the Renin-Angiotensin-Aldosterone System, August 1, 2014    Clinical Article

16 The effect of infrequent low-dose rosuvastatin on the lipid profile Canadian Journal of Cardiology, August 6, 2014    Clinical Article

17 Hydroxyurea and growth in young children with sickle cell disease Pediatrics, August 28, 2014    Clinical Article

18 Effects of lipophilic statins for heart failure: a meta-analysis of 13 randomised controlled trials Heart, Lung, and Circulation, August 8, 2014    Evidence Based Medicine    Review Article    Clinical Article

19 Statins and delirium during critical illness: A multicenter, prospective cohort study Critical Care Medicine, July 23, 2014    Clinical Article

20 Are Fibromyalgia patients cognitively impaired? Objective and subjective neuropsychological evidence Arthritis Care & Research , August 13, 2014    Clinical Article

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physicianmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close