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The sensitivity and specificity of hyperglycosylated hCG (hhCG) levels to reliably diagnose clinical IVF pregnancies at 6 days following embryo transfer
Journal of Assisted Reproduction and Genetics, 05/07/2012
Strom CM et al. – A single serum hyperglycosylated hCG (hhCG) measurement can determine a clinical pregnance at 6 days post embryo transfer.
Methods- A 4 center prospective blinded clinical trial was performed with patients undergoing IVF–ET.
- Patients had blood drawn and submitted for hhCG analysis on the day of ET and at days 4, 6, 8, and 12 thereafter.
- First morning urines were collected and submitted for hhCG analysis on days 0, 4, 6, 8, 10 and 12.
- Fifty–six of 58 enrolled patients completed the study.
- There were 25 clinical and 6 biochemical pregnancies.
- For blastocyst transfers, a single serum or urine hhCG measurement identified pregnancies (both biochemical and clinical) at 6 days post ET with 100% sensitivity and specificity.
- There were 6 biochemical pregnancies, all following blastocyst transfers.
- All of these pregnancies were identified by lower values.