Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 05/07/2012
Wagner R et al. – Renal sinus fat (RSF) is associated with exercise–induced albuminuria independently of sex, age, visceral adipose tissue (VAT) and mean arterial peak pressure (MAPP) in a non–diabetic cohort at diabetic risk. The authors conclude that perivascular adipose tissue (PVAT) in the renal sinus may play a role in the pathogenesis of microalbuminuria.Methods
- Non-diabetic individuals at increased risk of type 2 diabetes were recruited into the Tübingen Lifestyle Intervention Program (TULIP); 146 participants took part in the analysis.
- RSF was measured in axial MRI sections at the level of the renal artery. Urine was collected before and after exercise stress testing.
- Participants (age 47 ± 12 years; mean ± SD) reached a mean exercise load of 176 ± 49 W, with a mean arterial peak pressure (MAPP) of 112 ± 14 mmHg.
- After adjusting for sex, age, visceral adipose tissue (VAT) and MAPP during exercise, RSF was significantly associated with postexercise albumin/creatinine ratio (ACR; p = 0.006).
- No association between RSF and baseline BP could be observed after adjusting for confounders (p = 0.26), and there was no association between RSF and baseline ACR either (p = 0.2).