Sitagliptin add-on to low dosage sulphonylureas: efficacy and safety of combination therapy on glycaemic control and insulin secretion capacity in type 2 diabetes
International Journal of Clinical Practice,  Clinical Article

Harashima SI et al. – The combination therapy with sitagliptin and low dosage sulphonylureas was safe and effective for glycaemic control. Glucagon loading test indicated that 1 year administration of sitagliptin and sulphonylureas preserved insulin secretion capacity.

Methods
  • Eighty–two subjects were sequentially recruited for the 52–week, prospective, single arm study.
  • Sitagliptin was added on to sulphonylureas (glimepride or gliclazide) with or without metformin.
  • The primary endpoint was a change in A1C.
  • The secondary endpoints were changes in BMI, insulin secretion capacity, blood pressure and urinary albumin excretion, unresponsive rate, and hypoglycaemia.
  • Insulin secretion capacity was evaluated by glucagon loading test.

Results
  • Change in A1C was – 0.80% (95% CI – 0.90 to – 0.68) (p < 0.001).
  • Change in BMI, systemic and diastolic blood pressure, and urinary albumin excretion were –0.38 kg/m2 (95% CI –0.72 to –0.04) (p < 0.05), –6.7/–3.6 mmHg (95% CI –10.0 to –3.4/–4.8 to –2.4) (p < 0.001), and –43.2 mg/gCr (95% CI –65.7 to –20.8) (p < 0.001) respectively.
  • Mild hypoglycaemia was observed in three cases.
  • The unresponsive rate was 6.1%.
  • Glucagon loading test showed that 0–min and 6–min CPR at baseline and 52–week were not significantly changed: 0–min CPR, 1.58 ± 0.58–1.71 ± 0.73 ng/ml; 6–min CPR, 3.48 ± 1.47–3.58 ± 1.21 ng/ml.
  • Insulin secretion capacity, CPI and SUIT index at baseline did not predict the efficacy of the combination therapy.
  • The final dosages of glimepiride and gliclazide were 1.44 ± 0.90 mg and 34.5 ± 15.3 mg respectively.
  • The dosage of sitagliptin was increased from 50 mg to 69.0 ± 24.5 mg in 52–week.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Physician Assistant

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Physician Assistant Articles

1 Dengue outlook for the World Cup in Brazil: An early warning model framework driven by real-time seasonal climate forecasts The Lancet Infectious Diseases, May 27, 2014    Clinical Article

2 Dance for Parkinson's: A new framework for research on its physical, mental, emotional, and social benefits Complementary Therapies in Medicine, June 17, 2014    Review Article

3 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

4 Statins in the elderly: an answered question Current Opinion in Cardiology, June 9, 2014    Evidence Based Medicine    Review Article    Clinical Article

5 The role of vitamin supplementation in the prevention of cardiovascular disease events Full Text Clinical Cardiology, May 30, 2014    Free full text    Review Article

6 Effects of low dose versus high dose human growth hormone on body composition and lipids in adults with GH deficiency: A meta-analysis of placebo-controlled randomized trials Pituitary, May 9, 2014    Evidence Based Medicine    Review Article

7 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

8 Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States BMJ, June 24, 2014    Evidence Based Medicine    Clinical Article

9 The effectiveness of metoprolol versus atenolol on prevention of all-cause and cardiovascular mortality in a large Chinese population: A cohort study International Journal of Cardiology, June 27, 2014    Clinical Article

10 Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis New England Journal of Medicine, May 21, 2014    Evidence Based Medicine    Clinical Article

11 Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. preventive services task force Annals of Internal Medicine, April 8, 2014    Evidence Based Medicine    Clinical Article

12 The effectiveness of yoga for depression: a critical literature review Issues in Mental Health Nursing, April 9, 2014    Review Article

13 Fish consumption and lung cancer risk: systematic review and meta-analysis Nutrition and Cancer, April 18, 2014    Evidence Based Medicine    Review Article

14 A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative Seminars in Arthritis and Rheumatism, June 19, 2014    Review Article

15 Cardiovascular risk and statin use in the United States Full Text Annals of Family Medicine, May 13, 2014    Free full text    Clinical Article

16 Effect of fixed dose combination treatment on adherence and risk factor control among patients at high risk of cardiovascular disease: randomised controlled trial in primary care BMJ, June 16, 2014    Evidence Based Medicine    Clinical Article

17 Tofacitinib versus methotrexate in rheumatoid arthritis New England Journal of Medicine, June 20, 2014    Evidence Based Medicine    Clinical Article

18 Statins and physical activity in older men the osteoporotic fractures in men study JAMA Internal Medicine, June 12, 2014    Evidence Based Medicine    Clinical Article

19 Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial The Lancet Oncology, June 18, 2014    Clinical Article

20 Naloxegol for opioid-induced constipation in patients with noncancer pain New England Journal of Medicine, June 13, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physicianmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close