Paradoxical change in atrial fibrillation dominant frequencies with baroreflex-mediated parasympathetic stimulation with phenylephrine infusion

Journal of Cardiovascular Electrophysiology, 05/11/2012

Despite baroreflex–mediated parasympathetic effect, PE produced a slowing of AF along with lengthening of ERP, while parasympathetic blockade also slowed DF. It is therefore likely that the direct and indirect adrenergic effects of PE on atrial electrophysiology are more prominent than its parasympathetic effects.


  • The protocol was performed in 27 patients (24M, 59±1 years old) prior to AF ablation.
  • For 10 patients in AF, PE was infused until systolic blood pressure increased ≥30 mmHg.
  • Electrograms were recorded in the left atrium before and after PE.
  • DFs of each recording were calculated offline.
  • Atrial effective refractory periods (ERPs) were measured before and after PE in 11 patients who were in sinus rhythm during the procedure.
  • DFs were also measured in 6 patients in AF before and after complete parasympathetic blockade with atropine (0.04 mg/kg).


  • PE resulted in increased RR intervals during sinus rhythm (1170±77 to 1282±85 ms, p = 0.03) and AF (743±32 to 826±30 ms, p = 0.03), consistent with parasympathetic effect on the sinus and AV node, respectively.
  • DFs were decreased by PE in the left atrium (6.2±0.2 to 6.0±0.2 Hz, p = 0.004).
  • Correspondingly, atrial ERPs significantly increased from 218±13 to 232±11 ms (p = 0.04).
  • Atropine resulted in a decreasing trend in DF in the left atrium (5.9±0.1 to 5.8±0.1 Hz, p = 0.07).

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