Smartest Doc
Progression of osteoporosis in patients with COPD: A 3-year follow up study
Respiratory Medicine, 04/24/2012
Clinical Article
Graat–Verboom L et al. – The prevalence of osteoporosis increased over a 3–year period in patients with COPD. Baseline risk factors for the development of osteoporosis are osteopenia at the trochanter and vitamin D deficiency.
Methods- Clinically stable COPD outpatients were included.
- Lung function parameters, body composition measures, six minute walk distance, DXA–scan and X–spine were assessed at baseline and repeated after 3 years.
- Prevalence of osteoporosis in COPD patients increased from 47% to 61% in 3 years mostly due to an increase of vertebral fractures.
- Lower baseline T–score at the trochanter independently increased the risk for the development of osteoporosis.
- Additionally, baseline vitamin D deficiency increased this risk 7.5–fold.