The risk of gestational diabetes mellitus among Mexican women with a history of infertility and polycystic ovary syndrome

Fertility and Sterility, 04/20/2012

Pregnant Mexican women with a history of infertility and polycystic ovary syndrome (PCOS) are at increased risk for developing gestational diabetes mellitus (GDM). This risk should be considered beginning early in the second trimester for a timely intervention and to improve the maternal–fetal prognosis.

Methods

  • Group 1 (n = 52), women with a history of infertility and PCOS, and group 2 (n = 52), women without PCOS.
  • Inclusion criteria were singleton pregnancy with ≤13 weeks of gestation.
  • Exclusion criteria were pregestational diabetes mellitus and/or concomitant diseases.
  • Diagnosis of GDM was based on a 3–hour, 100–g oral glucose tolerance test (GTT) performed during the second trimester.

Results

  • The incidence of GDM was 26.9% and 9.6% for groups 1 and 2, respectively (RR = 2.8; 95% confidence interval 1.08–7.2).
  • No other between–group differences were observed in the incidence of miscarriage, preterm birth, premature rupture of membranes, preeclampsia, stillbirth, fetal malformations, or small or large for gestational age newborns.

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