Setting priorities for comparative effectiveness research in inflammatory bowel disease: Results of an international provider survey, expert rand panel, and patient focus groups
Inflammatory Bowel Disease, 04/30/2012Cheifetz AS et al.
The authors systematically developed a list of high–priority inflammatory bowel disease (IBD) topics for Comparative effectiveness research (CER) based on a survey of gastroenterologists, expert review, and patient input. This list may guide IBD research toward the most important CER studies.
Following the Institute of Medicine’s approach, the authors developed and administered a survey to gastroenterologists asking for important CER topics in IBD.
Two patient focus groups were convened to solicit additional CER studies.
CER topics were presented to the expert panel using the RAND/UCLA methodology.
Following initial ratings, the panel met to discuss and re-rate priorities.
The top 10 CER topics were identified using a point-allocation system.
Responses were collated into 234 CER topics across 21 categories, of which 87 were prioritized for discussion and re-rated.
Disagreement regarding priorities was observed in 5 of 87 studies.
They utilized a point-allocation system to prioritize the top-10 CER topics.
These related to comparing the effectiveness of: biomarkers in IBD; withdrawal of anti-tumor necrosis factor (TNF) or immunomodulators for Crohn's disease in remission; mucosal healing as an endpoint of treatment; infliximab levels versus standard infliximab dosing; anti-TNF monotherapy versus combination therapy in patients failing thiopurines; safety of long-term treatment options; anti-TNF versus thiopurines for prevention of postoperative recurrence; and treatment options for steroid-refractory UC.
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