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Effect of statin treatment on three-month outcomes in patients with stroke-associated infection: a prospective cohort study
European Journal of Neurology, 04/23/2012
Clinical Article
Yeh PS et al. – Statin use was not associated with a better functional outcome or survival in patients with stroke–associated infection.
Methods- In this prospective observational cohort study, 514 patients with acute ischaemic stroke or transient ischaemic attack (mean age, 74 ± 11 years; men, 48%) with infection occurring in the first 7 days after admission were included.
- The authors examined the effect of in-hospital statin treatment on mortality and favorable functional outcome (modified Rankin Scale score ≤2) at 3 months follow-up.
- Infection occurred at 0.93 ± 1.49 days after admission.
- All patients had not received statin treatment prior to admission, and 121 patients (24%) received statin at 1.71 ± 1.28 days after admission.
- Follow-up at 3 months was completed for 511 patients (99%).
- National Institutes of Health Stroke Scale score and Charlson index were the most important independent predictors of mortality and functional outcome.
- Univariate [hazard ratio (HR), 0.82; 95% confidence intervals (CI), 0.47-1.42] and multivariate (HR, 1.68; 95% CI, 0.79-3.56) Cox regression analysis showed that statin did not significantly decrease the morality.
- In propensity analysis, statin treatment still had no significant association with mortality (HR, 1.54; 95% CI, 0.68-3.47) in the multivariate analyses after adjusting for age, sex, and propensity score.