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Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus-positive oropharyngeal carcinoma prior to 1970
The Laryngoscope, 05/09/2012
Chenevert J et al. – The two cases can be added to the other 15 cases of human papillomavirus (HPV)–positive primary oropharyngeal SCC identified in the department from 1956 to 1969. When determining the incidence of HPV–positive oropharyngeal SCC before the 1970s, a correction factor of about +13% (2/15) accounting for modern pathologic workup of SCCUP during the last couple of decades may be appropriate.