PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma
International Journal of Cancer, 04/30/2012
Gawecka JE et al. – Phosphoprotein enriched in astrocytes 15 (PEA15) blocks neuroblastoma migration through inhibition of ERK/RSK2 signaling. PEA15 expression levels correlate with favorable clinical features suggesting that PEA15 limits metastatic progression of neuroblastoma. Thus, PEA15 and its partners ERK and RSK2 are potential targets for the development of new therapeutics to impede progression of minimal residual disease in patients with high–risk neuroblastoma.