Decline in Infantile Hypertrophic Pyloric Stenosis in Germany in 2000–2008

Pediatrics, 04/04/2012

De Laffolie J et al. – The infantile hypertrophic pyloric stenosis (IHPS) incidence declined by –38% nationwide. A parallel decline in SIDS displayed a different pattern in regional distribution; thus, a common cause was unlikely. The regional differences indicated that etiologic factors remained unresolved.


  • Data were extracted from the public report of health (Gesundheitsberichterstattung des Bundes).
  • The authors collected the numbers of IHPS (International Classification of Diseases, 10th Revision [ICD-10], code 40.0), SIDS (ICD-10, R95), and live births (LB; male/female) in each federal state for 2000–2008.


  • The IHPS incidence declined in Germany from 2000 (3.2086/1000 LB [range: 1.67–5.33]) to 2008 (2.0175/1000 LB [1.74–3.72]; P = .005).
  • The recorded incidence was highly variable in different federal states and over time.
  • The SIDS incidence also declined during the same time period (2000, median: 0.759/1000 LB [interquartile range: 0.54–1.029]; 2008, median: 0.416/1000 LB [interquartile range: 0.285–0.6485]; P = .0255).
  • However, the SIDS regional distribution was different from that of IHPS.

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