Sorafenib for Treatment of Hepatocellular Carcinoma: A Systematic Review
Digestive Diseases and Sciences, 03/30/2012
Evidence Based Medicine
Xie B et al. – Treatment with sorafenib results in statistically significant, but clinically modest, improvements in OS, TTP, and DCR. For patients with hepatitis B, response seems to be poorer than for those with hepatitis C. The frequency of hand–foot syndrome seems to be higher when sorafenib is used in advanced cirrhosis and is combined with 5–FU drugs. It is not clear that sorafenib combined with other treatments is more effective than sorafenib alone.Methods
- The authors conducted a systematic review using the PRISMA guidelines to identify prospective studies on sorafenib used alone or in combination with systemic and/or loco regional anti-tumor therapy for treating advanced HCC.
- Theyidentified 21 prospective trials of sorafenib treatment alone (7) or combined with other treatment (14).
- In randomized, placebo-controlled trials, sorafenib prolonged overall survival by 2.3–2.8 months, extended the time to tumor progression by 1.4–2.7 months, and increased disease control by 11–19 %.
- OS and DCRs were lowest for studies with the highest percentage of hepatitis B patients.
- Most studies reported major side effects (diarrhea, fatigue, and hand–foot syndrome) in <15 % of patients, with greater incidence in patients with advanced cirrhosis and those treated with sorafenib in combination with 5-FU drugs.