Helicobacter pylori Infection: Sequential Therapy Followed by Levofloxacin-Containing Triple Therapy provides a Good Cumulative Eradication Rate
Helicobacter, 04/06/2012  Clinical Article

Manfredi M et al. – Sequential therapy as first–line and levofloxacin–containing triple therapy as second–line represent a good combination to eradicate Helicobacter pylori infection in only two rounds.

• The authors treated 231 consecutive Helicobacter pylori-positive patients by sequential therapy and they verified the eradication 8–10 weeks after treatment by stool antigen test.
• Patients positive for stool antigen test received levofloxacin-containing triple therapy, as second-line therapy, according to Italian Guidelines and they were again submitted to the fecal test 8–10 weeks after the end of treatment.

• In the first-line regimen, they obtained an eradication rate of 92.6%, in the second-line of 75.0% and as cumulative result they achieved a 97.8% of eradication, in per-protocol analysis.