Helicobacter pylori Infection: Sequential Therapy Followed by Levofloxacin-Containing Triple Therapy provides a Good Cumulative Eradication Rate

Helicobacter, 04/06/2012

Sequential therapy as first–line and levofloxacin–containing triple therapy as second–line represent a good combination to eradicate Helicobacter pylori infection in only two rounds.

Methods

  • The authors treated 231 consecutive Helicobacter pylori-positive patients by sequential therapy and they verified the eradication 8–10 weeks after treatment by stool antigen test.
  • Patients positive for stool antigen test received levofloxacin-containing triple therapy, as second-line therapy, according to Italian Guidelines and they were again submitted to the fecal test 8–10 weeks after the end of treatment.

Results

  • In the first-line regimen, they obtained an eradication rate of 92.6%, in the second-line of 75.0% and as cumulative result they achieved a 97.8% of eradication, in per-protocol analysis.

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