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Activated innate immunity and the involvement of CX3CR1–fractalkine in promoting hematuria in patients with IgA nephropathy

Cox SN et al. – The authors found a defect in antigen handling in peripheral blood mononuclear cells of immunoglobulin A nephropathy patients with a specific increase of CX3CR1. This constitutive upregulation of glomerular and urinary fractalkine suggests an involvement of the CX3CR1–fractalkine axis in the exacerbation of gross hematuria. [more...]