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Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation

Shekar K et al. – The most common mechanisms by which extracorporeal membrane oxygenation (ECMO) affects pharmacokinetics are sequestration in the circuit, increased volume of distribution, and decreased drug elimination. While lipophilic drugs and highly protein–bound drugs (eg, voriconazole and fentanyl) are significantly sequestered in the circuit, hydrophilic drugs (eg, β–lactam antibiotics, glycopeptides) are significantly affected by hemodilution and other pathophysiologic changes that occur during ECMO. [more...]

Journal of Critical Care

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