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CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV

Pressey JG et al. – These findings demonstrate that CD133+ cells from A–RMS and E–Rhabdomyosarcoma (RMS) cell lines are characterized by a myogenically primitive phenotype. These cells have the capacity to form colonies in vitro and are more resistant to chemotherapy than CD133 cells. CD133 expression may denote a subset of RMS cells with an important role in tumorigenesis and treatment failure. [more...]

Pediatric Blood & Cancer

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