We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Prospective randomized trial of moderately strenuous aerobic exercise after an implantable cardioverter defibrillatorCirculation, May 29, 2015  Clinical Article
2Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort studyBMJ, May 29, 2015  Clinical Article  Evidence Based Medicine
3Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trialBMJ, May 29, 2015  Clinical Article  Evidence Based Medicine
4Bilateral conjunctival swelling after dental extractionThe Lancet Infectious Diseases, May 29, 2015
5Both low and high 24-hour diastolic blood pressure are associated with worse cognitive performance in type 2 diabetes: The Maastricht StudyDiabetes Care, May 29, 2015
6Distinct and synergistic contributions of epithelial stress and adaptive immunity to functions of intraepithelial killer cells and active celiac diseaseGastroenterology, May 29, 2015  Clinical Article
7Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis?Annals of Rheumatic Diseases, May 29, 2015  Clinical Article
8Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): A randomised, controlled clinical trialAnnals of Rheumatic Diseases, May 29, 2015  Clinical Article
9A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesionsAnnals of Rheumatic Diseases, May 29, 2015  Clinical Article
10MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: Results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trialAnnals of Rheumatic Diseases, May 29, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Time is muscle in acute heart failureEuropean Society of Cardiology News, May 29, 2015
2Cognitive impairment predicts worse outcome in heart failureEuropean Society of Cardiology News, May 29, 2015
3Obesity and mood disorders increase peripartum cardiomyopathy riskEuropean Society of Cardiology News, May 29, 2015
4Depression associated with 5-fold increased mortality risk in heart failure patientsEuropean Society of Cardiology News, May 29, 2015
5Starting antiretroviral treatment early improves outcomes for HIV-infected individualsNational Institute of Allergy and Infectious Disease - News, May 29, 2015
6New evidence confirms link between newer contraceptive pills and higher blood clot risksUniversity of Nottingham News, May 29, 2015
7Soy supplements don't improve asthmaNorthwestern University News, May 29, 2015
8Nearly 1 in 7 Hispanic/Latino adults has some hearing lossNIH News, May 29, 2015
9Stuttering linked to ability to hear rhythmThe Hearing Review, May 29, 2015
10Exercise offers cancer survivors significant improvements in quality of lifeYale School of Medicine News, May 29, 2015

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PCA3 useful for early diagnosis of prostate cancer

Based on a meta-analysis reported in the Chinese Medical Journal, prostate cancer antigen 3 (PCA3) can be used for the early diagnosis of prostate cancer and to avoid unnecessary biopsies, with a sensitivity of 0.82, a specificity of 0.962, a positive likelihood ratio of 2.39, a negative likelihood ratio of 0.51, and a diagnostic odds ratio of 4.89.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).

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