Tobacco and alcohol use significantly increase risk for ESCC
Based on a meta-analysis (n=5 studies) reported in the American Journal of Gastroenterology, the combined use of tobacco and alcohol increased the risk for esophageal squamous cell carcinoma (OR=3.28) compared with non-users; users of tobacco or alcohol alone had a 20%-30% increased risk of esophageal squamous cell carcinoma compared to non-users.
Calcium reduces CRC risk
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.
DCL1 is a tumor suppressor in melanoma patients
As reported in Modern Pathology, down-regulation of cytoplasmic and nuclear DLC1 is associated with poor overall survival and disease-specific 5-y survival in all melanoma patients. Combined down-regulation of cytoplasmic and nuclear DCL1 was associated with the worse survival for patients with metastatic melanoma.