Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma
Journal of Cancer Research & Clinical Oncology, 06/04/2012
Hegyi M et al. – The findings suggest that there was correlation between methotrexate (MTX) exposure and the incidence of toxicity. Higher serum concentrations at 48 h were associated with a better 5–year overall survival (OS) and event–free survival (EFS). These results suggest that higher MTX exposure may lead to serious side effects, but it also improves treatment outcome.